Relationship Of Significant Weight Loss And Prognosis In Cancer Patients

Prognostic effect of weight loss prior to chemotherapy in


...91-7. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Dewys WD , Begg C , Lavin PT , Band PR , Bennett JM , Bertino JR , Cohen MH , Douglass HO Jr , Engstrom PF , Ezdinli EZ , Horton J , Johnson GJ , Moertel CG , Oken MM , Perlia C , Rosenbaum C , Silverstein MN , Skeel RT , Sponzo RW , Tormey DC . Abstract The prognostic effect of weigh...


New hope for rapid weight loss associated


... loss and resulting in muscle loss and general weakness. It’s not just a matter of a loss of appetite. “Rapid weight loss — more than 5 percent of body weight over three to six months — is likely due to this hyper-metabolic condition,” Belury said. The National Cancer Institute estimates that cachexia is the immediate cause of death in 20 percent to 40 percent of cancer patients. Finding answers to los...


Obesity and Its Impact on Breast Cancer : Tumor Incidence


...ing author: Jennifer A. Ligibel, MD, Dana-Farber Cancer Institute, 450 Brookline Ave, Y1234, Boston, MA 02215; email: _link_ . American Society of Clinical Oncology Educational Book 2013 ASCO Annual Meeting Figures Overview A positive association between obesity and the risk of incident postmenopausal breast cancer has been consistently observed in epidemiologic st...


Relationship Between Cancer Patients' Predictions of


...ere excluded from enrollment in SUPPORT if they were non–English speaking, had a planned admission of less than 72 hours, were pregnant, or had died or been discharged from the hospital within 48 hours of study entry. All study patients were asked to identify a surrogate decision maker, whom patients "would want to help [their] doctor[s] make a decision about [their] medical care if [they] w...


Lung Cancer Causes, Symptoms, Treatment


...hitis or pneumonia , can be a sign of lung cancer. Symptoms of metastatic lung tumors depend on the location and size. About 30% to 40% of people with lung cancer have some symptoms or signs of metastatic disease. Lung cancer most often spreads to the liver , the adrenal glands, the bones, and the brain. Metastatic lung cancer in the liver may cause a loss of appetite, feeling full early on whi...


Weight, Physical Activity, Diet, and Prognosis in Breast


..., 1.07 to 1.69; P = .013) and a 58% increased risk of breast cancer death (HR, 1.58; 95% CI, 1.15 to 2.16; P = .0048) after adjustment for confounding variables. Women with C-peptide levels higher than 2.5 ng/mL had an approximate four-fold increased risk of breast cancer death compared with women with a C-peptide level lower than 1.7 ng/mL (HR, 3.90; 95% CI, 1.16 to 13.13; P for trend = .028). A...


Cancer Cachexia : Mechanisms and Clinical Implications


...ted a challenge for researchers using time-consuming and expensive tools such as doubly labelled water and indirect calorimetry. However research using these methods has revealed that although resting energy expenditure may be elevated in cachectic patients, total energy expenditure is reduced because weight-losing cancer patients reduce the magnitude of their energy deficit through reductions in physic...


Is Serum Albumin an Independent Predictor of Survival in


...e important prognostic factors in high-risk early-stage epithelial ovarian cancer. [4,5] Performance status, tumor histology, and residual tumor volume are independent predictors of prognosis in patients with stage III epithelial ovarian cancer. [4] Additionally, the presence or absence of ascites and diameter of the largest residual tumor nodule are statistically important predictors of survival...


Elevated Serum C - Reactive Protein as a Prognostic Marker


...lege of Medicine, Seoul, Korea. Corresponding author. Corresponding author: Dr. Dae Joon Kim, Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. Tel: 82-2-2228-8126, Fax: 82-2-393-3652, Email: [email protected] Received 2010 Nov 3; Revised 2011 Jan 26; Accepted 2011 Feb 22. © Copyright : Yonsei University Col...


Cancer's Devastatingly Effective Weight


...ficult to determine, and can be complicated by factors such as tumor location and therapeutic measures taken.   Loss of appetite may also be an indirect effect of depression.   But cancer itself may secrete contributing factors.   Tumors implanted in animals and causing anorexia sometime resolve when the tumor is removed.   Survival of some with certain forms of cancer...


Obesity and Breast Cancer : Page 2 of 3 - Cancer Network


...age 2 of 3 The Obesity and Breast Cancer Connection: Advancing the Agenda Weight Loss and Prognosis in Dietary Interventional Studies Given that many women gain weight after breast cancer diagnosis, there are relatively few data from observational studies describing the relationship between weight loss after diagnosis and disease outcomes. There are also no studies examining the impact of purposeful weight loss on ...


Age, comorbidity, treatment decision and prognosis in lung


...s refused other treatment proposed or if the committee so decided. The following definitions were established: comorbidity as any disease present 12 months before the date of cancer diagnosis, active treatment as chemotherapy with or without radiotherapy or radical radiotherapy alone, weight loss as a decrease of > 5% of habitual weight in the previous 6 months, best support...


British Journal of Cancer - Do patients with weight loss


...ients suffered from during chemotherapy, and on whether weight loss altered the amount of chemotherapy delivered. In addition, we aimed to assess whether stabilisation of weight during treatment had any effect on outcome. Figures and Tables Patients This study reviewed data that had been recorded prospectively on the RMH lung unit research database between 1994 and March 20...


Does body weight affect cancer risk


... regulate cell growth, such as insulin-like growth factor-1 (IGF-1) Proteins that influence how the body uses certain hormones, such as sex hormone-binding globulin Does losing weight reduce cancer risk? Research on how losing weight might lower the risk of developing cancer is limited. Still, there’s growing evidence that weight loss might reduce the risk of breast cancer (after menopause), more aggressive forms ...


The Skinny' on Obesity, Cancer, and Losing


...Obesity is a global epidemic. [1] This public health crisis and the growing body of evidence linking obesity with cancer risk [2-4] have prompted the American Society of Clinical Oncology (ASCO) to launch an initiative addressing the issue of obesity, particularly as it affects cancer patients and survivors. A special session held during the ASCO annual meeting, entitled "ASCO Obesity Initiative: Weight of the Evidence," [5] expl...


Unintentional Weight Loss as the Sole Indication for


...ss Weight loss is used as an indication for colonoscopy. The rationale for this likely is because of the association of weight loss with many types of occult malignancy. One third of elderly patients with unintentional weight loss were diagnosed with malignancy. 1 – 4 Gastrointestinal malignancy is the most common type of occult malignancy diagnosed in patients with unintentional weight loss, and colorectal ...


Weight loss and mortality risk in patients with


...nown—it has been suggested to be a gradual and graded process, 13 but it could also be a step-wise process where phases of weight stability and weight change are distinct. Our study provides evidence for the latter, as it is shown that mean weight change > 12 months before death is small or non-existent, whereas it is steeply increasing in the last 12 months prior to death (Figure  4 A)...


Do patients with weight loss have a worse


...men depended on histology. The majority of patients treated for NSCLC were treated within the context of clinical trials with a minimum of three cycles of platinum-containing regimens, including MVP, carboplatin and vinorelbine, and docetaxel plus carboplatin ( Ellis et al, 1995 ; Smith et al, 2001 ). In addition, 11 patients with NSCLC were treated with single agent vinorelbine on the basis of t...


Gastric Carcinoma. Information about Gastric Cancer


...drug for the palliative treatment of advanced gastric cancer.[ 9 ] Pre-operative downstaging of locally advanced disease with chemotherapy may enable resection of previously inoperable cancers. Currently there is no indication to recommend second-line chemotherapy. Its role should remain in the context of a clinical trial. Second-line palliative chemotherapy following failure of first-line chemotherapy i...


Ghrelin Level and Body Weight Loss After Esophagectomy for


...und Ghrelin is a peptide hormone predominantly produced by endocrine cells in the oxyntic mucosa of the stomach and is an endogenous ligand for the growth hormone secretagogue receptor. Ghrelin plays an important role in regulating appetite, food intake, and energy metabolism. We investigated the correlation between clinicopathologic factors and plasma ghrelin concentration before and after esophagectomy with gastric ...


Mechanisms of Cancer Cachexia - Home


...ed lipolytic response to isoprenaline, a nonselective β-adrenergic agonist, and CL316243, a specific β3-adrenergic agonist, as well as forskolin and isobutylmethylxanthine, both of which increase cAMP levels. There was no effect on basal lipolysis. Thus adipocytes from ZAG knockout animals show an inverse response to lipolytic stimulation as do adipocytes from cachectic cancer patients ( ...


Obesity and Cancer Risk - National Cancer Institute


...studies. The relationship between obesity and breast cancer may be affected by the stage of life in which a woman gains weight and becomes obese. Epidemiologists are actively working to address this question. Weight gain during adult life, most often from about age 18 to between the ages of 50 and 60, has been consistently associated with risk of breast cancer after menopause. The increased risk of postmenopausal breast cancer ...


Breast cancer - Wikipedia, the free encyclopedia


...ave been linked to the risk for breast cancer. Dietary factors which may increase risk include a high fat diet, [43] high alcohol intake, [44] and obesity related high cholesterol levels. [45] [46] Dietary iodine deficiency may also play a role. [47] Evidence for fiber is unclear. A 2015 review found that studies trying to link fiber intake with breast cancer produced mixed results. [48] In 2016 a tentative association between low ...


Impact of Underweight after Treatment on Prognosis of


...the date after completion of the primary treatment to the date of clinically proven recurrence. OS was defined as the time that elapsed from the date of diagnosis to the date of cancer-related death or end of the study. 2.4. Statistical Methods Kruskal-Wallis, Mann-Whitney , and Chi-square tests were used to determine differences in clinicopathologic characteristics among underweight, normal to ove...


The Role of Obesity in Cancer Survival and Recurrence


... combined with lifestyle modification ( 101, 102 ). For those severely obese, bariatric surgery (including vertical-banded gastroplasty, gastric bypass, and laparoscopic adjustable gastric banding) offers the most assured approach to weight loss as assessed by both short- and long-term outcomes ( 101 , 103 , 104 ). Weight loss at 1 to 2 years may be as high as 32% of in...


Nutrition in Cancer Care


...nergy deficit alone does not explain the pathogenesis of cachexia. Several factors have been proposed.[ 3 ] Mediators including cytokines, neuropeptides, neurotransmitters, and tumor-derived factors are postulated to contribute to this syndrome.[ 4 ] Products of host tissues, such as tumor necrosis factor-α, interleukin-1, interleukin-6, interferon-γ, and leukemia inhibitor fac...


Clinical and genetic predictors of weight gain in patients


...SNPs alone, and a combination of both sets of SNPs. The epistatic model using both sets of SNPs showed the best fit with smallest deviance and so was chosen to interpret our results as shown in Table 5 . Also included are the results of multivariate quartile analysis. Paying particular attention to the SNPs that are significant at the 12-month or final 18-month points either individually or part of an intera...


Weight change during chemotherapy changes the prognosis


...2007, 2: 260-265. View Article Kroenke CH, Chen WY, Rosner B, Holmes MD: Weight, weight gain, and survival after breast cancer diagnosis. J Clin Oncol. 2005, 23: 1370-1378. View Article PubMed Bonomi PBN, Fishman D: Weight gain during breast cancer evaluated in relation to disease-free survival (DFS). Breast Cancer Research And Treatment. 1984, 4: 339- Chlebo...


Obesity and Breast Cancer - Cancer Network


...ion and anastrozole, compared with those treated with ovarian ablation and tamoxifen, despite the fact that the two treatments were equivalent in the study population as a whole. Obesity at diagnosis has also been linked to a higher risk of recurrence in recent adjuvant chemotherapy trials. In the Adjuvant Docetaxel vs Epirubicin Based Regimen (ADEBAR) study, a randomized trial that assessed the value of adding a taxane to anthracycli...


Definition of cancer cachexia : effect of weight loss


...a population that differed for self-reported functional aspects of quality of life. A weight loss ≥10% did, however, define a group of patients with different physician-reported performance scores and grip strengths. In marked contrast, a multifactor cachexia profile that was based on weight loss, food intake, and inflammatory status defined a cachectic population that had both a lower su...


Predictors for Weight Loss in Head and Neck Cancer


... earlier. Although all of the results of this systematic review should be interpreted with the above limitations, the results may disclose a trend. Back to Top | Article Outline Conclusion This systematic review provided an overview of the current knowledge concerning the independent predictors of weight loss in patients with HNC undergoing RT. It included 22 studies involving 6159 patients. We have identified 3 strong-evidence predic...


Relationship of CDX2 Loss with Molecular Features and


...; 95% CI, 1.98-9.86; P = 0.0003), and inversely with LINE-1 hypomethylation (for a 30% decline; OR, 0.33; 95% CI, 0.16-0.69; P = 0.0031). Considering multiple hypothesis testing, any of the associations with P values between 0.05 and 0.005 (including those with CIMP-low, high tumor grade, p53, stage IV, and β-catenin) might represent chance events. In multivariate analysis, CDX2 loss was not significantly associated with...